Clinical Trials for Cancer Treatments
There are MANY other clinical trials. University of Pennsylvania has a new CHF grant that is still in the laboratory phase, but should have a clinical trial for treating lymphoma using CAR T immunotherapy within the next two years. Stay tuned!

Below you will find more details on three clinical trials for cancer treatments.

Lymphoma – University of Pennsylvania
Bendamustine is a chemotherapy drug that is used to treat various types of cancer in people, including lymphoma, but it has not yet been evaluated in dogs with cancer. The purpose of this study is to evaluate different doses of bendamustine in dogs with lymphoma to evaluate its safety and effectiveness.
Dogs may be eligible for this trial after relapsing from a standard chemotherapy protocol for lymphoma. Dogs will be actively enrolled in the trial for 21 days, consisting of 5 study visits and 2 doses of bendamustine. All standard of care tests and procedures and all study-related procedures performed during study visits 1 through 5 will be paid for by the study.
For more information, please call the study coordinator at 215-573-6610 or email:  vcic@vet.upenn.edu
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Osteosarcoma – University of Missouri
The University of Missouri is running a trial to determine the safety and effectiveness of immunotherapy as a treatment for osteosarcoma. They use cells from the cancer to create a vaccine to trigger the dog’s own immune system to fight the cancer. Participation in this study is limited to a number of breeds (including Berners) that have osteosarcoma of the radius or ulna, but have no metastasis to the lungs, previous treatment, or significant comorbidities. Dogs must be able to receive treatments at the U of MO, as well as all necessary follow-up visits. 70% of the cost of limb sparing surgery, and 100% of the recheck exams, bloodwork, and immunotherapy treatments will be paid for by the study. Any complications needing treatment would be paid for by the dog’s owner. Use this survey -  www.missouri.qualtrics.com.  to determine if your dog is eligible.  Contact: www.cvmclinicaltrials@missouri.edu">www.cvmclinicaltrials@missouri.edu for more information.

Note: Limb sparing means that instead of amputating the affected limb, only the area affected by the primary tumor and its surroundings are removed. The area where bone is removed would have a prosthesis and/or other reinforcement put in place of the bone. This is one of the major reasons they are only enrolling dogs for which the tumor(s) is in a position lower down the leg. Tumors farther up the leg on a big dog can have complications due to weight stress, movement, and other reasons, therefore they are not accepting those patients.
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Osteosarcoma – Colorado State University
This trial is also using the CAR T-cell treatment for dogs that have osteosarcoma that has metastasized to the lungs – and only the lungs. They must be available to go to CSU for the treatments. This website, www.csuanimalcancercenter.org,  details the requirements for participation, as well as the process and costs.